The 21st century has been revolutionary for the field of clinical genomics, with major advancements and breakthroughs over the years. It is now considered an instrumental tool in clinical and preventive medicine and has been used on a day-to-day basis to complement current clinical practice. However, with advancements in genomics comes greater bioethical concerns, which becomes increasingly complex with more cutting-edge technology. Some of the major ethical concerns include obtaining informed consent, possibility for genetic enhancements and eugenics, genomic equity and (...) potential discrimination and cloning. It is imperative that we appreciate the benefits of genomic medicine in complementing traditional practices, identify and address the ethical concerns with relation to the practice of genomic medicine, and to ensure a common goal of improving human lives. With these in mind, the practice of genomics can have maximum impact in the collective health of the population, with greater benefit to all. (shrink)

This paper argues against a thesis that Shashi Tharoor seems to accept: that R.K. Narayan’s style is bound up with a very specific context, of people left behind by the times in South India. It cannot deal with other subject matter. I present a little fiction to challenge the thesis.

This paper presents folk impressions of the University of Manchester’s difficulties in becoming a great university, but by means of a fiction imitating a distinguished writer from the Indian subcontinent. The impressions concern past efforts and the difficulties they faced.

Scotus believes it is clear that the pursuit of happiness is not psychologically supreme. If the will necessarily pursued happiness, it follows that whenever both x and y are open, x rather than y promotes happiness. But Scotus replies that sometimes we are aware that x rather than y promotes happiness, but we can simply choose to pursue neither x nor y. If we suspend further action, we choose to be indifferent toward happiness. Scotus agrees with Anselm's argument from responsibility. (...) In his view, the affection for justice is nobler than the affection for advantage, because it causes us to will something that is not directed toward ourselves. It manifests freedom in the will, because an agent who is capable of choosing the just rather than the advantageous is not necessitated by nature to pursue only his own advantage. (shrink)

Spade 1988 sugges t s tha t t he r e are ac tua l l y two theo r i e s t o address t h i s ques t i o n t o , an ear l y one and a l a t e r one . 2 Most o f the presen t pape r i s a deve l o pmen t o f t h i s i dea . I sugges t (...) tha t ear l y work by Sherwood and o the r s was a s tudy o f quan t i f i e r s : the i r semant i c s and t he e f f e c t s o f con t e x t on i n f e r e n ce s t ha t can be made f r om quan t i f i e d te rms . La te r , i n the hands o f Bur l e y and o the r s , i t changed i n t o a s tudy o f someth i n g e l se , a s tudy o f what I ca l l g loba l quan t i f i c a t i o n a l e f f e c t . In sec t i o n 1 , I exp l a i n what these two op t i o n s are. (shrink)

En este trabajo presentamos la traducción del latín al español de la carta de Giovanni Pico della Mirandola a su amigo Andrea Corneo de Urbino con introducción y notas. En el texto, Pico expone sus puntos de vista respecto una de las cuestiones que tuvo en vilo a los intelectuales del siglo XV: la de la elección entre la vida activa y la contemplativa. La carta trata, además, del llamado "incidente de Arezzo", un confuso episodio en el que el joven (...) conde raptó a la esposa de Giuliano Mariotto de' Medici. A lo largo del texto Pico se revela como imitador de los autores clásicos latinos, entre ellos, Séneca, Horacio, Gelio, Plauto, Terencio y especialmente Cicerón. In this paper, we offer the translation from latin to spanish of Giovanni Pico della Mirandola's letter to his friend Andrea Corneo from Urbino with introduction and notes. In this text, Pico presents his points of view about one of the most important problems along the fifteenth century: the choice between active and contemplative life. In addition, the letter enter upon the so-called "incident of Arezzo", a confusing episode in which the young count kidnapped Giuliano Mariotto de' Medici's wife. Along the text, Pico reveals himself as classical latin authors's imitator, among others, Seneca, Horace, Gellius, Plautus, Terence and specially Cicero. (shrink)

En este trabajo presentamos la traducción del latín al español de la carta de Giovanni Pico della Mirandola a su amigo Andrea Corneo de Urbino con introducción y notas. En el texto, Pico expone sus puntos de vista respecto una de las cuestiones que tuvo en vilo a los intelectuales del siglo XV: la de la elección entre la vida activa y la contemplativa. La carta trata, además, del llamado "incidente de Arezzo", un confuso episodio en el que el joven (...) conde raptó a la esposa de Giuliano Mariotto de' Medici. A lo largo del texto Pico se revela como imitador de los autores clásicos latinos, entre ellos, Séneca, Horacio, Gelio, Plauto, Terencio y especialmente Cicerón. In this paper, we offer the translation from latin to spanish of Giovanni Pico della Mirandola's letter to his friend Andrea Corneo from Urbino with introduction and notes. In this text, Pico presents his points of view about one of the most important problems along the fifteenth century: the choice between active and contemplative life. In addition, the letter enter upon the so-called "incident of Arezzo", a confusing episode in which the young count kidnapped Giuliano Mariotto de' Medici's wife. Along the text, Pico reveals himself as classical latin authors's imitator, among others, Seneca, Horace, Gellius, Plautus, Terence and specially Cicero. (shrink)

J. L. Mackie argued that if there were objective moral properties or facts, then the supervenience relation linking the nonmoral to the moral would be metaphysically queer. Moral realists reply that objective supervenience relations are ubiquitous according to contemporary versions of metaphysical naturalism and, hence, that there is nothing especially queer about moral supervenience. In this paper we revive Mackie's challenge to moral realism. We argue: (i) that objective supervenience relations of any kind, moral or otherwise, should be explainable rather (...) than sui generis; (ii) that this explanatory burden can be successfully met vis-à-vis the supervenience of the mental upon the physical, and in other related cases; and (iii) that the burden cannot be met for (putative) objective moral supervenience relations. (shrink)

This book traces the development of Plato's theory in its historical context, from the Socratic conception of virtue, knowledge and moral motivation to the revised Platonic conception, including the Theory of recollection, the Theory of forms, Platonic love, and the divisions of the soul.

We argue that there is a conflict among classical theism's commitments to divine simplicity, divine creative freedom, and omniscience. We start by defining key terms for the debate related to classical theism. Then we articulate a new argument, the Aloneness Argument, aiming to establish a conflict among these attributes. In broad outline, the argument proceeds as follows. Under classical theism, it's possible that God exists without anything apart from Him. Any knowledge God has in such a world would be wholly (...) intrinsic. But there are contingent truths in every world, including the world in which God exists alone. So, it's possible that God contingently has wholly intrinsic knowledge. But whatever is contingent and wholly intrinsic is an accident. So, God possibly has an accident. This is incompatible with classical theism. Finally, we consider and rebut several objections. (shrink)

Terence Parsons presents a lively and controversial study of philosophical questions about identity. Because many puzzles about identity remain unsolved, some people believe that they are questions that have no answers and that there is a problem with the language used to formulate them. Parsons explores a different possibility: that such puzzles lack answers because of the way the world is (or because of the way the world is not). He claims that there is genuine indeterminacy of identity in (...) the world. He articulates such a view in detail and defends it from a host of criticisms. (shrink)

In the first post World War II identity theories (e.g., Place 1956, Smart 1962), mind brain identities were held to be contingent. However, in work beginning in the late 1960's, Saul Kripke (1971, 1980) convinced the philosophical community that true identity statements involving names and natural kind terms are necessarily true and furthermore, that many such necessary identities can only be known a posteriori. Kripke also offered an explanation of the a posteriori nature of ordinary theoretical identities such as that (...) water = H2O. We identify the kinds and substances involved in theoretical identities by certain of their contingent properties. What we discover when we discover a theoretical identity is the underlying nature of the kind that we identify by those contingent properties. Now, of course, it was being a posteriori, not being contingent, that mattered to the identity theorists anyway, so the necessity of identity is not, in itself, damaging to mind brain identity theories. However, Kripke also argued persuasively that the alleged mind brain identities could not be treated in the same way as ordinary theoretical identities. We "identify" pain by feeling it, and surely how it feels is an essential property of pain, not a contingent property. Thus, a mind body identity theory must provide a different explanation of why its identities are a posteriori. A new wave of materialists has appeared on the scene with a new strategy for explaining [1] the a posteriori nature of its alleged identities. The strategy is to locate the explanation for the a posteriori nature of mind body identities, not on the side of the world, but on the side of the mind -in different ways of thinking about or imagining, or in different concepts. Thus, on this new view, there is only one property—this brain process type, which is identical with this pain.. (shrink)

I distinguish two broad approaches to vagueness that I call "robust" and "wimpy". Wimpy construals explain vagueness as robust (i.e., does not manifest arbitrary precision); that standard approaches to vagueness, like supervaluationism or appeals to degrees of truth, wrongly treat vagueness as wimpy; that vagueness harbors an underlying logical incoherence; that vagueness in the world is therefore impossible; and that the kind of logical incoherence nascent in vague terms and concepts is benign rather than malignant. I describe some implications for (...) logic, semantics, and metaphysics. (shrink)

Terence Cuneo presents a new argument for moral realism. According to the normative theory of speech, speech acts are generated by an agent's altering her normative position with regard to her audience. In doing so she takes on rights and responsibilities, some of which are moral and objective: these are a necessary condition of speech.

Terence Irwin presents a historical and critical study of the development of moral philosophy over two thousand years, from ancient Greece to the Reformation. Starting with the seminal ideas of Socrates, Plato, and Aristotle, he guides the reader through the centuries that follow, introducing each of the thinkers he discusses with generous quotations from their works. He offers not only careful interpretation but critical evaluation of what they have to offer philosophically. This is the first of three volumes which (...) will examine the history of ethics in the Socratic tradition, up to the late 20th century. (shrink)

The central purpose of this essay is to consider some of the more prominent reasons why realists have rejected the Humean theory of motivation. I shall argue that these reasons are not persuasive, and that there is nothing about being a moral realist that should make us suspicious of Humeanism.

Covering over 1000 years of classical philosophy from Homer to Saint Augustine, this accessible, comprehensive study details the major philosophies and philosophers of the period--the Pre-Socratics, Socrates, Plato, Aristotle, Stoicism, Epicureanism, and Neoplatonism. Though the emphasis is on questions of philosophical interest, particularly ethics, the theory of knowledge, philosophy of mind, and philosophical theology, Irwin includes discussions of the literary and historical background to classical philosophy as well as the work of other important thinkers--Greek tragedians, historians, medical writers, and early (...) Christian writers. The most complete one-volume introduction to ancient philosophy available, the book will be an invaluable survey for students of philosophy and classics and general readers. (shrink)

War and Border Crossings brings together renowned scholars to address some of the most pressing problems in public policy, international affairs, and the intercultural issues of our day. Contributors from widely varying disciplines discuss cross-cultural ethical issues and international topics ranging from American international policy and the invasion and occupation of Iraq to domestic topics such as immigration, the war on drugs, cross-cultural bioethics and ethical issues involving American Indian tribes. The culture clashes discussed in these essays raise serious questions (...) about what principles ought to inform the negotiating of conflicts in order to achieve, or at least approach, outcomes that are fundamentally just, fair, responsible, and ethical. (shrink)

Transvaluationism makes two fundamental claims concerning vagueness. First, vagueness is logically incoherent in a certain way: vague discourse is governed by semantic standards that are mutually unsatisfiable. But second, vagueness is viable and legitimate nonetheless; its logical incoherence is benign.

Aristotle''s account of vice presents a puzzle: (1) Viciouspeople must be guided by reason, since they act on decision(prohairesis), not on their non-rational desires. (2) And yet theycannot be guided by reason, since they are said to pay attention totheir non-rational part and not to live in accordance with reason. Wecan understand the conception of vice the reconciles these two claims,once we examine Aristotle''s account of (a) the pursuit of the fine andof the expedient; (b) the connexion between vice and (...) the pursuit ofpleasure; (c) the particular kind of regret to which the vicious personis subject. (shrink)

I propose a way of formulating scientific laws and magnitude attributions which eliminates ontological commitment to mathematical entities. I argue that science only requires quantitative sentences as thus formulated, and hence that we ought to deny the existence of sets and numbers. I argue that my approach cannot plausibly be extended to the concrete "theoretical" entities of science.

I invoke the conceptual machinery of contemporary possible-world semantics to provide an account of the metaphysical status of "bridge laws" in intertheoretic reductions. I argue that although bridge laws are not definitions, and although they do not necessarily reflect attribute-identities, they are supervenient. I.e., they are true in all possible worlds in which the reducing theory is true.

I argue for three principle claims. First, philosophers who seek to integrate the semantic and the intentional into a naturalistic metaphysical worldview need to address a task that they have thus far largely failed even to notice: explaining into- level connections between the physical and the intentional in a naturalistically acceptable way. Second, there are serious reasons to think that this task cannot be carried out in a way that would vindicate realism about intentionality. Third, there is much to be (...) said for an irrealist, non-eliminativist, naturalistic approach to intentionality that I call "preservative irrealism". (shrink)